Lab Publications (2007-present)

Primary

Stein BJ, Fiebig A, and Crosson, S. 2020. Feedback control of a two-component signaling system by an Fe-S-binding receiver domain. mBio 11: pii: e03383-19. doi: 10.1128/mBio.03383-19.

Wytock TP, Zhang M, Jinich A, Fiebig A, Crosson S, and Motter AE. 2020. Extreme antagonism arising from gene-environment interactions. Biophys. J. doi: 10.1016/j.bpj.2020.09.038.

Varesio LM, Willett JW, Fiebig A, and Crosson S. 2019. A carbonic anhydrase pseudogene sensitizes select Brucella lineages to low CO2 partial pressure. J. Bacteriol. 201: pii: e00509-19. doi: 10.1128/JB.00509-19.

 

Fiebig A. 2019. Role of Caulobacter Cell Surface Structures in Colonization of the Air-Liquid Interface. J. Bacteriol. 201. pii: e00064-19. doi: 10.1128/JB.00064-19. 

Fiebig A, Varesio LM, Alejandro Navarreto X, and Crosson S. 2019. Regulation of the Erythrobacter litoralis DSM 8509 general stress response by visible light. Mol. Microbiol. 112: 442-460. doi: 10.1111/mmi.14310.

 

Hershey DM, Porfírio S, Black I, Jaehrig B, Heiss C, Azadi P, Fiebig A, and Crosson S. 2019. Composition of the holdfast polysaccharide from Caulobacter crescentus. J. Bacteriol. 201: pii:JB.00276-19. doi: 10.1128/JB.00276-19.

 

Reyes Ruiz LM, Fiebig A, and Crosson S. 2019. Regulation of bacterial surface attachment by a network of sensory transduction proteins. PLoS Genetics 15:e1008022. doi: 10.1371/journal.pgen.1008022.

 

Herrou J, Willett JW, Fiebig A, Czyż DM, Cheng JX, Ultee E, Briegel A, Bigelow L, Babnigg G, Kim Y, and Crosson S. 2019. Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence. J Bacteriol. pii: JB.00134-19. doi: 10.1128/JB.00134-19.

 

Hershey, D.M., Fiebig, A. and Crosson, S. 2019. A genome-wide analysis of adhesion in Caulobacter crescentus identifies new regulatory and biosynthetic components for holdfast assembly. mBio 10: pii: e02273-18. doi: 10.1128/mBio.02273-18.

Herrou, J., Willett, J.W., Fiebig, A., Varesio, L.M., Czyż, D.M., Cheng, J.X., Ultee, E., Briegel, A., Bigelow, L., Babnigg, G., Kim, Y., and Crosson, S. 2019. Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus. Mol. Microbiol. 111: 637-661. doi: 10.1111/mmi.14178.

Hentchel, K.L., Reyes Ruiz, L.M., Curtis, P.D., Fiebig, A., Coleman, M.L., and Crosson, S. 2019. Genome-scale fitness profile of Caulobacter crescentus grown in natural freshwater. ISME J. 13: 523-536. doi: 10.1038/s41396-018-0295-6.

Tien, M.Z., Stein, B.J., and Crosson, S. 2018. Coherent feedforward regulation of gene expression by Caulobacter σT and GsrN during hyperosmotic stress. J. Bacteriol. 200; pii: JB.00349-18. doi: 10.1128/JB.00349-18.

Tien, M.Z., Fiebig, A., Crosson, S. 2018. Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival. eLife 7: e33684. doi: 10.7554/eLife.33684.

 

Herrou, J., Czyż, D.M., Fiebig, A., Willett, J.W., Kim, Y., Wu, R., Babnigg, G., Crosson, S. 2018. Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor. J. Biol. Chem. 293: 7437-7456. doi: 10.1074/jbc.RA118.002045.

 

Wytock, T.P., Fiebig, A., Willett, J.W., Herrou, J., Fergin, A., Motter, A.E., Crosson, S. 2018. Experimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate. PLoS Genetics 14: e1007284. doi: 10.1371/journal.pgen.1007284.

 

Luebke, J.L., Eaton, D.S., Sachleben, J.R., Crosson, S. 2018. Allosteric control of a bacterial stress response system by an anti-σ factor. Mol. Microbiol. 107: 164-179. doi: 10.1111/mmi.13868.

 

Czyż D.M., Willett, J.W., Crosson, S. 2017. Brucella abortus induces a Warburg shift in host metabolism that is linked to enhanced intracellular survival of the pathogen. J. Bacteriol. 199 doi: 10.1128/JB.00227-17.

 

Herrou J., Willett J.W., Czyż D.M., Babnigg G., Kim Y., and Crosson S. 2016. Conserved ABC transport system regulated by the general stress response pathways of Alpha- and Gammaproteobacteria. J. Bacteriol. doi:10.1128/JB.00746-16.

 

Czyż D.M., Jain-Gupta N., Shuman H.A., Crosson S. 2016. A dual-targeting approach to inhibit Brucella abortus replication in human cells. Sci. Rep. 6: 35835. doi: 10.1038/srep35835.

 

Baric R.S., Crosson S., Damania B., Miller S.I., Rubin E.J. 2016. Next-generation high-throughput functional annotation of microbial genomes. mBio 7:e01245-16 doi:10.1128/mBio.01245-16.

 

Willett, J.W., Herrou, J., Czyż D.M., Cheng, J.X., and Crosson, S. 2016. Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis. Vaccine 34: 5073-5081. DOI: 10.1016/j.vaccine.2016.08.076.

 

Herrou, J., Choi, V.M., Bubeck Wardenburg, J., and Crosson, S. 2016. Activation mechanism of the Bacteroides fragilis cysteine peptidase, Fragipain. Biochemistry 55: 4077-4084. DOI: 10.1021/acs.biochem.6b00546.

 

Eaton, D.S., Crosson, S., and Fiebig, A. 2016. Proper control of Caulobacter crescentus cell-surface adhesion requires the general protein chaperone, DnaK. J. Bacteriol. 198: 2631-2642. doi:10.1128/JB.00027-16.

 

Choi, V.M., Herrou, J., Hecht, A.L., Teoh., W.P., Turner, J.R., Crosson, S., Bubeck Wardenburg, J. 2016. Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis. Nature Medicine 22: 563-567. doi: 10.1038/nm.4077.

Meyer, P.A., Socias, S., Key, J., Ransey, E., Tjon, E.C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J.,Neau, D., Rajashankar., K., Anderson, K., et al. 2016. Data publication with the structural biology data grid supports live analysis. Nature Communications 7: 10882. doi:10.1038/ncomms10882.

 

Herrou J., Czyż D.M., Willett J.W., Kim H-.S., Chhor G., Babnigg G., Kim Y., and Crosson S. 2016. WrpA is an atypical flavodoxin-family protein under regulatory control of the Brucella abortus general stress response system. J. Bacteriol. 198: 1281-1293. doi:10.1128/JB.00982-15.

 

Aakre C.D., Herrou J., Phung T.N., Perchuk B.S., Crosson S., and Laub M.T. 2015. Evolving new protein-protein interaction specificity through promiscuous intermediates. Cell 163: 594-606.

 

Herrou J., Willett J.W. and Crosson S. 2015. Structured and dynamic disordered domains regulate the activity of a multi-functional anti-σ factor. mBio 6: e00910-15. DOI:10.1128/mBio.00910-15.

 

Lubin, E.A., Henry, J.T., Fiebig, A., Crosson, S. and Laub, M.T. 2015. Identification of the PhoB regulon and role of PhoU in the phosphate-starvation response of Caulobacter crescentus. J. Bacteriol. 198: 187-200. doi:10.1128/JB.00658-15.

 

Willett J.W., Herrou J., Briegel A., Rotskoff G., and Crosson S. 2015. Structural asymmetry in a conserved signaling system that regulates division, replication and virulence of an intracellular pathogen. Proc. Natl. Acad. Sci. USA 112: E3709-3718.

 

Wright C.S., Banerjee S., Iyer-Biswas S., Crosson S., Dinner A.R., Scherer N.F.  2015.  Intergenerational continuity of cell shape dynamics in Caulobacter crescentus.  Sci. Rep. 5: 9155.  DOI: 10.1038/srep09155.

 

Dupré E, Herrou J, Lensink MF, Wintjens R, Vagin A, Lebedev, A., Crosson, S., Villeret, V., Locht, C., Antoine, R., and Jacob-Dubuisson, F.  2015.  Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS. PLoS Pathogens 11: e1004700. doi:10.1371/journal.ppat.1004700.

 

Kim H.-S. Willett J.W. Jain-Gupta N., Fiebig A. and Crosson S. 2014. The Brucella abortus virulence regulator, LovhK, is a sensor kinase in the general stress response signaling pathway.  Mol. Microbiol. 94: 913-925. doi: 10.1111/mmi.12809.

 

Iyer-Biswas S., Wright C.S., Henry J.T., Burov S., Lin Y., Crooks G.E., Crosson S., Dinner A.R., and Scherer N.F.  2014.  Scaling laws governing stochastic growth and division of single bacterial cells.  Proc. Natl. Acad. Sci. USA.  111: 15912-15917.

 

Czyz, D.M., Potluri, L.P., Jain-Gupta, N., Riley, S.P., Martinez, J.J., Steck, T.L., Crosson, S., Shuman, H.A., Gabay, J.E. 2014. Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens. MBio. e01534-14. doi: 10.1128/mBio.01534.

Schrader, J.M., Zhou, B., Li, G.W., Lasker, K., Childers, W.S., Williams, B., Long, T., Crosson, S., McAdams, H.H., Weissman, J.S., Shapiro, L. 2014. The coding and noncoding architecture of the Caulobacter crescentus genome. PLoS Genetics. e1004463. doi: 10.1371/journal.pgen.1004463.

Fiebig, A., Herrou, J., Fumeaux, C., Radhakrishnan, S.K., Viollier, P.H., and Crosson, S.  2014.  A cell cycle and nutritional checkpoint controlling bacterial surface adhesion.  PLoS Genetics: e1004101. doi: 10.1371/journal.pgen.1004101.

 

Henry, J.T. and Crosson, S. 2013.  Chromosome replication and segregation govern the biogenesis and inheritance of inorganic polyphosphate granules.  Mol. Biol. Cell 24: 3177-3186.

Kim, H.-S., Caswell, C.C., Foreman, R., Roop, R.M., and Crosson, S. 2013. The Brucella abortus general stress response system regulates chronic mammalian infection and is controlled by phosphorylation and proteolysis. J. Biol. Chem. 288: 13906-13916.

Herrou, J. and Crosson, S. 2013. myo-inositol and D-ribose ligand discrimination in an ABC periplasmic binding protein. J. Bacteriol. 195: 2379-2388.

Lin, Y., Li, Y., Crosson, S., Dinner, A.R., and Scherer, N.F. 2012. Phase resetting reveals network dynamics underlying a bacterial cell cycle. PLoS Comput. Biol. 8: e1002778. doi: 10.1371/journal.pcbi.1002778.

Herrou, J., Rotskoff, G., Luo, Y., Roux, B., and Crosson, S.  2012.  The structural basis of a protein partner switch that regulates the general stress response of α-proteobacteria. Proc. Natl. Acad. Sci. USA 109: E1415-1423.

 

Foreman, R., Fiebig, A.*, and Crosson, S.* 2012.  The LovK-LovR two-component system is a regulator of the general stress pathway in Caulobacter crescentus.  J. Bacteriol. 194: 3038-3049.

Heaton, B., Herrou, J., Blackwell, A.E., Wysocki, V.H., and Crosson, S.  2012.  Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. J. Biol. Chem. 287:12098-12110.

 

Boutte, C.C., Henry, J.T., and Crosson, S.  2012.  ppGpp and polyphosphate modulate cell cycle progression in Caulobacter crescentus. J. Bacteriol. 194: 28-35

 

Boutte, C.C. and Crosson, S.  2011.  The complex logic of stringent response regulation in Caulobacter crescentus: starvation signaling in an oligotrophic environment. Mol. Microbiol. 80: 695-714.

 

van Stokkum I.H., Gauden M., Crosson S., Van Grondelle, R., Moffat, K., and Kennis, J.T.  2011.  The primary photophysics of the Avena sativa phototropin 1 LOV2 domain observed with time-resolved emission spectroscopy. Photochem. Photobiol. 87: 534-541.

Lin, Y., Crosson, S*. and Scherer, N.F.*  2010.  Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion. Mol. Syst. Biol. 6: 445. doi:10.1038/msb.2010.95.

 

Purcell, E.B., McDonald, C.A., Palfey, B.A., and Crosson, S.  2010.  An analysis of solution structure and signaling mechanism of LovK, a sensor histidine kinase integrating light and redox signals.  Biochemistry 49: 6761-6770. 

 

Herrou, J., Foreman, R., Fiebig, A., and Crosson, S.  2010. A structural model of anti-anti-sigma inhibition by a two-component receiver domain: the PhyR stress response regulator. Mol. Microbiol. 78: 290-304.

          

Marks, M.E., Castro-Rojas, C.M., Teiling, C., Du, L., Kapatral, V. Walunas, T. and Crosson, S.  2010. The genetic basis of laboratory adaptation in Caulobacter crescentus. J. Bacteriol. 192: 3678-3688.

 

Fiebig, A.* Castro-Rojas, C.M., Siegal-Gaskins, D., and Crosson, S.*  2010. Interaction specificity, toxicity, and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems.  Mol. Microbiol. 77: 236-251.

 

Alexandre, M., Purcell, E.B, Van Grondelle, R., Robert, B., Kennis, J.*, and Crosson,S.*  2010.  Electronic and protein structural dynamics of a photosensory LOV histidine kinase.  Biochemistry 49: 4752-4759. 

 

Dalton, K.M. and Crosson, S.  2010.  A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex.  Biochemistry 49: 2205-2215.

 

Siegal-Gaskins, D., Ash, J., and Crosson, S.  2009. Model-based deconvolution of cell cycle time-series data reveals gene expression details at high resolution. PLoS Comput Biol 5: e1000460; doi:10.1371/journal.pcbi.1000460.

 

Boutte, C.C., Srinivasan, B.S., Flannick, J.A., Novak, A.F., Martens, A.T., Batzoglou, S., Viollier, P.H., and Crosson, S.  2008.  Genetic and computational identification of a conserved bacterial metabolic module.  PLoS Genet 4: e1000310; doi:10.1371/journal.pgen.1000310.

 

Siegal-Gaskins, D., and Crosson, S.  2008.  Tightly-regulated and heritable division control in single bacterial cells.  Biophys J. 95: 2063-2072.

 

Purcell, E.B., Siegal-Gaskins, D., Rawling, D.C., Fiebig, A., and Crosson, S. 2007.  A photosensory two-component system regulates bacterial cell attachment.  Proc. Natl. Acad. Sci. USA. 104:18241-18246.

Invited Reviews

Herrou J., Crosson S., and Fiebig, A. 2017. Structure and function of HWE/HisKA2-family sensor histidine kinases. Curr. Opin. Microbiol. 10.1016/j.mib.2017.01.008.

Willett, J.W., and Crosson, S. 2017. Atypical modes of bacterial histidine kinase signaling. Mol. Microbiol. 103: 197-202. doi: 10.1111/mmi.13525.

Fiebig, A., Herrou, J., Willett, J.W., and Crosson. S.  2015.  General stress signaling in the Alphaproteobacteria.  Annu. Rev. Genetics 49. doi: 10.1146/annurev-genet-112414-054813.

 

Boutte, C.C. and Crosson, S. 2013. Bacterial lifestyle shapes stringent response activation. Trends Microbiol. 21: 174-180.

 

Herrou, J. and Crosson, S. 2011.  Function, structure, and mechanism in bacterial photosensory LOV proteins.  Nature Rev. Microbiol. 9: 713-723.

Henry, J.T. and Crosson, S.  2011.  Ligand binding PAS domains in a genomic, cellular, and structural context.  Annu. Rev. Microbiol. 65: 261-286.

 

Idnurm, A., and Crosson, S.  2009.  The photobiology of microbial pathogenesis.  PLoS Pathog 5: e1000470. doi:10.1371/journal.ppat.1000470.

 

Purcell, E.B. and Crosson, S.  2008.  Photoregulation in prokaryotes.  Curr. Opin. Microbiol. 11:168-178.

 

Kennis, J.T.M, and Crosson, S.  2007.  A bacterial pathogen sees the light.  Science 317:1041-1042.

Meeting Reports

Crosson, S., and Dacks, J.B.  2012.  Cell biology of microorganisms and the evolution of the eukaryotic cell.  Mol. Biol. Cell. 23: 974.  doi: 10.1091/mbc.E11-12-0974.

 

Alexandre G, Crosson S, Shimizu T, Msadek T.  2011.  Bacterial Moving and Shaking: the 11th BLAST Meeting.  Mol Microbiol. 81: 8-22.

 

Book Chapters

Purcell, E.B., Boutte, C.C., and Crosson, S.  2008.  Two-Component Signaling Systems and Cell Cycle Control in Caulobacter crescentus.  In Bacterial Signal Transduction: Networks and Drug Targets.  ed. R. Utsumi.  Landes-Eurekah.  Austin, TX.

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